NAD+
/Nicotinamide Adenine Dinucleotide/
Nicotinamide Adenine Dinucleotide (NAD⁺) is a coenzyme found in all living cells. It plays a role in many biological processes, including energy metabolism and cellular function. NAD⁺ exists in both oxidised (NAD⁺) and reduced (NADH) forms, and contributes to the conversion of nutrients into energy within the body.
NAD⁺ is also involved in processes such as DNA repair and the regulation of cellular activity.
Why NAD⁺ via IV Therapy?
IV administration allows for direct delivery of NAD⁺ into the bloodstream, bypassing the digestive system. This method may achieve higher serum concentrations compared to oral supplementation.
All IVT Sydney services are delivered following a clinical consultation to determine individual suitability. NAD⁺ IV infusions are available in various doses (250mg – 1000mg) and are prepared in line with appropriate clinical protocols.
Why NAD⁺ via IV Therapy?
IV administration allows for direct delivery of NAD⁺ into the bloodstream, bypassing the digestive system. This method may achieve higher serum
concentrations compared to oral supplementation.
All IVT Sydney services are delivered following a clinical consultation to determine individual suitability. NAD⁺ IV infusions are available in various doses (250mg – 1000mg) and are prepared in line with appropriate clinical protocols.
What to Expect
Before Your Infusion
We recommend staying well-hydrated and having a light meal 1–2 hours before your appointment. Some clients prefer a fasted state — in this case, we recommend water only for 4–6 hours prior.
NAD⁺ IV infusions are not recommended for individuals who are pregnant or breastfeeding, or those with liver, kidney, or heart conditions.
During Your Infusion
NAD⁺ infusions may take between 1 to 4 hours, depending on the dose and individual comfort. Some people may experience mild, temporary sensations such as:
Flushing or warmth
Tingling or muscle tightness
Light-headedness
A sense of heaviness in the body or chest
These effects typically subside by slowing the drip rate. Our clinicians monitor each client closely and adjust as needed.
Post-Infusion
We recommend avoiding alcohol for at least 72 hours after your infusion, as alcohol may interfere with metabolic processes and hydration.
Some clients choose to complement NAD⁺ IV therapy with a tailored nutrient blend to support hydration and comfort following the infusion.
Why Might Someone Choose NAD⁺ IV Therapy?
NAD⁺ supports a range of physiological processes, including:
Contributing to energy production at a cellular level (ATP synthesis)
Supporting metabolic activity
Participating in the regulation of circadian rhythm and sleep cycles
Assisting in normal DNA repair and cellular turnover
Helping maintain the function of the nervous and muscular systems
Some individuals choose NAD⁺ IV therapy as part of a wellness routine during times of increased physical demand, travel, or when focusing on lifestyle-related goals. All IVT Sydney services are personalised based on an individual health consultation.
Scientific Context
NAD⁺ continues to be studied in clinical and experimental settings. While some emerging research has explored its role in areas like ageing, metabolism, and neurological health, these applications remain investigational and are not approved therapeutic uses under the Therapeutic Goods Administration (TGA).
To learn more, you may wish to review current literature on NAD⁺ and cellular metabolism from reputable academic sources.
The following resources are provided for educational purposes only. IVT Sydney does not endorse or promote NAD⁺ as a treatment for any health condition. These studies are not intended to imply therapeutic outcomes from our services.
Further Reading: Research on NAD⁺
1. Safety and Tolerability of Nicotinamide Riboside and NAD⁺ Precursors in Humans: A Systematic Review
This 2023 review examines clinical trial data on NAD⁺-related compounds, showing they are generally well tolerated with emerging benefits in quality of life and energy metabolism.
🔗 Read on PubMed2. NAD⁺ in Aging: Molecular Mechanisms and Translational Implications
A comprehensive review of NAD⁺'s role in aging-related processes including DNA repair, mitochondrial function, and cell signalling.
🔗 Read on PubMed3. NAD⁺ Metabolism and the Control of Energy Homeostasis: A Balancing Act Between Mitochondria and the Nucleus
This article explores how NAD⁺ levels influence metabolic health, mitochondrial function, and cellular adaptation.
🔗 Read on Cardiovascular Research (Oxford)4. NAD⁺ Boosting to Support Metabolism and Healthy Aging
A review of current strategies to increase NAD⁺ levels, including precursors like NR and NMN, with discussion on potential metabolic benefits.
🔗 Read on Frontiers in Endocrinology5. NAD⁺ Supplementation and Physical Performance: Mechanistic Insight and Research Gaps
Discusses how NAD⁺ is involved in energy production and physical performance, including potential synergy with exercise.
🔗 Read on Sports Medicine Journal (Springer)6. Clinical Pilot Study Comparing IV NAD⁺, IV NR, and Oral NR in Healthy Adults
Preliminary data comparing the safety, tolerability, and effects on blood NAD⁺ levels of various delivery methods.
🔗 Read on medRxiv (Preprint)
Disclaimer:
IVT Sydney does not promote NAD+ infusions as a treatment for any disease or medical condition. The information provided on this website is for general informational purposes only and should not be considered medical advice. All services are subject to a clinical consultation and administered by qualified health professionals. Individual suitability, dosing, and administration frequency vary depending on health status and clinical assessment. Please consult a qualified healthcare professional to determine whether IV therapy is appropriate for your individual needs.